SPICE (simultaneous perfusion imaging with consecutive echoes) is a method that permits simultaneous estimation of DSC- and DCE-MRI parameters, in one acquisition, using a single dose of contrast agent. Conventional algorithms are used to obtain the perfusion and permeability parameters corrected for confounding recirculation and leakage effects. The proposed method does not require administration of a loading dose of contrast agent (traditionally employed for DSC), and pre-contrast spin density and native T1 calibration scans (traditionally required for DCE) have been eliminated.
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