Previous studies about resting-state functional activity reported that altered brain activity was demonstrated with type 2 diabetes and their findings were inconsistent ,which have not been quantitatively reviewed. Therefore, we conducted a quantitative meta-analysis including resting-state functional activity studies of patients with type 2 diabetes. Meta-analysis of pooled and subgroup meta-analyses found that type 2 diabetes patients showed abnormal brain activity mainly in default mode network(DMN) and visual-related regions. Our finding supports that type 2 diabetes could lead to diabetic brain activity alterations, which may correlate with cognitive impairment of type 2 diabetes patients.
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