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Abstract #4142

Quantitative susceptibility mapping (QSM) as a biomarker for evaluating white matter alterations in Parkinson’s disease

Xiaojun Guan1, Peiyu Huang1, Qiaoling Zeng1, Chunlei Liu2, Min Xuan1, Quanquan Gu1, Xiaojun Xu1, Nian Wang2, Nian Wang2, Xinfeng Yu1, Xiao Luo1, Jingjing Xu1, Wei Luo3, Yong Zhang4, and Minming Zhang1

1Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China, 2Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, NC, United States, 3Neurology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China, 4MR Research, GE Healthcare, Shanghai, People's Republic of China

Myelinated white matter showing diamagnetic susceptibility is important for information transfer in the brain. In Parkinson’s disease, the white matter is damaged secondary to nigral degeneration. Quantitative susceptibility mapping is a novel technique for noninvasive assessment of regional white matter ultrastructure, and provides different information to standard diffusion tensor imaging.

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