To measure temporal changes of the metabolite level during a memory task, proton functional MRS (fMRS) data with a single-voxel PRESS sequence were acquired at the precuneus and posterior cingulate brain region during a face-name association task using a 3 Tesla MRI scanner for the 28 cognitive normal elderly, 16 amnestic mild cognitive impairment, and 12 Alzheimer’s disease individuals. We measured the fMRS data three times at the eight-month interval. All of the acquired data were analyzed using LCModel software. Glx at the second trial increased significantly compared to that of the first trial in the novel condition.
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