A new T1 molecular MRI contrast agent specifically designed to be specific for oligomeric Aβ was developed by combining the commercially available gadolinium (Gd)-Dota with an oligomeric Aβ-specific DNA aptamer. We confirmed the protein size with Aβ polymerization in aspect of molecular masses when polymers were formed. We performed the following experiment in the cell level and AD-model mice. We identified a particular region with a significantly distinct T1 MRI signal, allowing for distinguishing Alzheimer's disease model mice from non-Tg mice.
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