Abstract #4143

The quantitative susceptibility mapping and non-motor symptoms of patients with early Parkinson disease

Chae Won Shin¹, Sun-Won Park^2,3, Jee-Young Lee¹, Jongho Lee⁴, Seon Lee⁵, Jae Myung Kim⁴, and Jung Hyo Lhim²

¹Department of Neurology, SNU-SMG Boramae Medical Center, Seoul, Korea, Republic of, ²Department of Radiology, SNU-SMG Boramae Medical Center, Seoul, Korea, Republic of, ³Department of Radiology, College of Medicine, Seoul National University, ⁴Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ⁵Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Korea, Republic of

This study is to evaluate the impact of quantitative susceptibility mapping (QSM) on regional distribution of iron deposition and its correlations with non-motor symptoms in patients with early Parkinson disease (PD). The QSM values of deep nuclei and clinical data using validated scales were obtained from patients. There were no differences in regional QSM values between patients and controls, and the QSM values were not correlated with any of motor or non-motor symptoms in PD patients. This study suggests that the QSM may not be a sensitive tool enough to use in patients with early PD.

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