Abstract #4127

Can measuring hippocampal atrophy over a 3 year interval with a fully automatic method be substantially less noisy than manual?

Keith S Cover¹, Ronald A van Schijndel², Adriaan Versteeg², Alberto Redolfi³, Paolo Bosco³, Soheil Damangi⁴, Bob W van Dijk¹, Hugo Vrenken^1,2, Giovanni B Frisoni^3,5, and Frederik Barkhof²

¹Physics and Medical Technology, VU University Medical Center, Amsterdam, Netherlands, ²Radiology, VU University Medical Center, Amsterdam, Netherlands, ³IRCCS SanGiovannidiDioFatebenefratelli, Italy, ⁴KarolinskaInstitutet, Stockholm, Sweden, ⁵University Hospitals and University of Geneva, Switzerland

The segmentation noise of hippocampal atrophy measurement methods can be measured using the back-to-back (BTB) reproducibility with the ADNI1 data set. Previous studies have only measured the segmentation noise over a one year interval. In the current study, two methods are shown to be substantially less noisy than manual hippocampal atrophy measurements over both 1 and 3 years - MAPS-HBSI and the recent FreeSurfer 6.0 Beta B (Build 20161008). Scatter plots of the 1 year versus 3 year BTB differences were found to be a particularly simple and effective way to display the segmentation noise of a method.

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