Alzheimer's Disease (AD) is the most common neurodegenerative disease, and is influenced by various environmental factors. In this study, we evaluate the effect of a high-fat, high-sugar ‘Western-type’ diet on the on the vascular response capacity to hypercapnia in a double transgenic (APP/PS1) mouse model of AD. We make use of Arterial Spin Labelling to investigate basal perfusion and cerebrovascular response to hypercapnia (CVR) in the hippocampus, cortex and thalamus.
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