Loss of spatial navigation skills is a typical feature in mild cognitive impairment. Here we investigate intrinsic activity using resting-stat functional magnetic resonance imaging within the subcortical regions, which is previously reported to be important in spatial navigation. Right hippocampus, pallidum and thalamus showed significant decreased regional homogeneity of local intrinsic activity in the patients, and the correlational trend between regional homogeneity and allocentric navigation performance showed significantly difference between patients and normal aging controls. These results showed evidences for the intrinsic subcortical activity damage and a possible compensatory mechanism of spatial navigation in the early mild cognitive impairment.
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