Aims of this large, multicenter study were to characterize baseline cervical cord atrophy in patients with multiple sclerosis (MS) compared with healthy controls, and to evaluate the modification of cervical cord cross-sectional area (CSA) over one-year of follow-up in such patients. Results indicated that baseline cord atrophy was present in MS patients vs controls, with a differential effect across phenotypes and a greater severity of atrophy in the progressive forms of the disease. Significant CSA decrease over time was found in relapsing remitting, primary progressive MS and in clinically worsened patients.
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