MS lesions are known to evolve in time, many showing signs of remyelination. To investigate this, we considered the changes in the regions around existing lesions of varying ages, to test the hypothesis that there is ongoing tissue damage in the regions around white matter lesions in MS. We found that the quantitative MT measured at 7T values in the region surrounding MS lesions decreased over the period of a longitudinal 6 month study. No systematic trend was found for the lesion core. This supports the hypothesis that an MS lesion causes ongoing damage in the region surrounding the lesion.
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