Aim of this study was to investigate the temporal evolution of resting state (RS) functional connectivity (FC) in patients with multiple sclerosis (MS) and its correlation with clinical and cognitive worsening. The predictive value of baseline functional network measures on the worsening of clinical disability/cognitive impairment was also explored. No significant RS FC changes were detected in healthy controls, while MS patients showed a complex pattern of longitudinal changes in the different networks, with a trend towards an increase (or stability) of RS FC in clinically stable MS patients, and a decrease of RS FC in clinically worsened MS patients.
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