We propose a novel 3D method called Dual-CEST, which simultaneously captures the CEST contrast stored in the longitudinal and transverse magnetisation of the bulk water. By including ADC events and a hexagonal spoiling scheme during the CEST preparation phase we collected the usually neglected transverse signal, generated by direct water saturation (a method we call NoXi-CEST). The unaffected longitudinal magnetisation is then acquired using a 3D-GRASE readout resulting in one (Dual-CEST) sequence (3:15 min) that provides XY-spectra, in addition to conventional Z-spectra, and producing additional CEST-contrast and B0-maps without loss of contrast or additional scan time (compared with conventional imaging).
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