The development of a novel CEST technique optimised to measure creatine in the human heart. After unsuccessful measurement of in vivo creatine concentrations using MTRasym, more robust model-based analysis methods based on spectral line shapes were tested and implemented on phantom data, with these model-based methods showing significant improvement to MTRasym analysis. Going forward, the developed pulse sequence combined with the model-based analysis methods are a promising step towards human cardiac creatine CEST.
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