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Abstract #2247

Repeated Binge Alcohol Intoxication Leads to Lower Choline-Containing Compound Signals in Rat Brain: An In Vivo Marker of Alcohol-Induced Neurobiological Abnormalities

Dong-Hoon Lee1,2, Do-Wan Lee3,4,5, Ji-Yeon Park6, Hae-Jin Park7, Kyu-Ho Song4,5, Yong Hyun Chung2, Dong-Cheol Woo8, and Bo-Young Choe4,5

1Brain and Mind Centre, University of Sydney, Sydney, Australia, 2Department of Radiological Science, Yonsei University, Wonju, Korea, Republic of, 3Ewha Brain Institute, Ewha Womans University, Seoul, Korea, Republic of, 4Department of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, 5Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul, Korea, Republic of, 6Department of Radiation Oncology, University of Florida, Gainesville, FL, United States, 7Department of Radiation Oncology, Ajou University School of Medicine, Suwon, Korea, Republic of, 8MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of

Alcohol is the most commonly abused intoxicating substance among young and middle-aged adults, and ranks highly as a cause of disability and mortality. A pattern of heavy consumption, called binge drinking, leads to various psychiatric disorders. We used in vivo proton magnetic resonance spectroscopy (1H MRS) to quantitatively assess neurochemical responses in hippocampus in a rat model of repeated-binge alcohol (RBA) intoxication. We determined that choline-containing compound, gamma-aminobutyric acid, and total N-acetyl-aspartate (tNAA: N-acetyl-aspartate + N-acetyl-aspartyl-glutamate) signals were highly sensitive to binge alcohol intoxication, which provides insights into neurochemical alterations associated with alcohol abuse.

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Abstract