Abstract #2246

Gray matter reduction is associated with poor treatment response in patients with schizophrenia: A voxel-based morphometry study with a strict control of multiple clinical variables

Jing-Ying Huang¹, Chih-Min Liu^2,3, Tzung-Jeng Hwang^2,3, Yu-Jen Chen¹, Yung-Chin Hsu¹, Hai-Gwo Hwu^2,3, and Wen-Yih Isaac Tseng^1,3,4,5

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, ³Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, ⁵Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

To investigate whether remitted and non-remitted patients with schizophrenia had distinctly different gray matter volumes, we used voxel-based morphometry (VBM) to analyze group difference by controlling all possible clinical variables. As compared with remitted patients, the non-remitted patients showed 10 brain areas with significantly decreased gray matter volume. Our results imply that remitted and non-remitted patients might have distinct patterns of gray matter reduction, and the characteristics of gray matter change might represent the structural correlate of treatment response in patients with schizophrenia.

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