Abstract #1714

Altered gray matter cerebral blood flow and its connectivity indicate a potential cognitive dysfunction of chronic subcortical stroke patients

Caihong Wang¹, Peifang Miao¹, Peng Li¹, Jingchun Liu², Lin Jiang³, Hao Liu¹, Dandan Zheng⁴, Zhenyu Zhou⁴, and Jingliang Cheng¹

¹Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China, ²Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, People's Republic of China, ³School of Medical Imaging, Tianjin Medical University, Tianjin, People's Republic of China, ⁴GE Healthcare MR Research China, Beijing

In order to investigate gray matter cerebral blood flow (CBF) and CBF connectivity alterations in chronic stroke patients, 60 patients and 60 controls were recruited to undergo 3D ASL technique. The patients exhibited increased CBFs in contralesional SFG, thalamus and ITG, and decreased CBF in ipsilesional Post_CG. Further analysis showed decreased CBF connectivity in patients in ipsilesional Pre_CG, MFG and Msfg. Importantly, the patients exhibited disconnections between the SFG and MFG, mSFG, Pre_CG. Current results suggest that stroke-induced cognitive dysfunction may be a connectivity disorder from the perspective of CBF connectivity.

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