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Abstract #1715

fMRI and spectroscopic characterization of sensory and pain processing in “pain-free” mice

Giovanna Diletta Ielacqua1, Aileen Schroeter1, Aline Seuwen1, David Buehlmann1,2, Jael Xandry3, John N. Wood4, and Markus Rudin1,3

1Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, 2Neuroscience Center Zurich, Zurich, Switzerland, 3Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland, 4Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom

FMRI has been widely used to assess changes in brain activity evoked by innocuous and noxious stimuli. However, stimulus-evoked fMRI (se-fMRI) measurements in mice have turned out challenging, and it is still under investigation whether and under which conditions se-fMRI applications in mice can lead to reliable readouts. Generally, se-fMRI could be a useful tool to characterize genetically modified mouse strains, such as mice exhibiting altered nociception. In this study, NaV1.7fl/fl:AdvCre mice were characterized with respect to neural processing of different types of peripheral stimuli and compared to a wildtype control group. Results of behavioral tests are compared to outcomes of fMRI and spectroscopic measurements.

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Abstract