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Abstract #1713

Effects of Lithium on resting-state fMRI in HIV-associated neurocognitive disorder

Yuchuan Zhuang1, Madalina Tivarus2, Eric H. Decloedt3,4, John A. Joska5, Jianhui Zhong2, and Giovanni Schifitto6

1Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, 2Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, United States, 3Department of Medicine, Stellenbosch University, South Africa, 4Department of Medicine, University of Cape Town, South Africa, 5Department of Psychiatry and Mental Health, University of Cape Town, South Africa, 6Department of Neurology, University of Rochester Medical Center, Rochester, NY, United States

This study firstly tested adjunctive lithium therapy in HIV patients with HAND. We examined the lithium effect using resting-state fMRI, and functional connectivity, amplitude of low-frequency fluctuation(ALFF) and fractional ALFF were calculated. We found significantly decrease of low-frequency oscillation and functional connectivity in lithium-treated group compared to placebo group, while neurocognitive performance was not different between the two groups.

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