Abstract #1712

Increased inter-hemispheric functional connectivity in restless legs syndrome using voxel-mirrored homotopic connectivity

Yong Zhang¹, Kang-An Li², Yun-Cheng Wu³, Zhenyu Zhou⁴, and Gui-Xiang Zhang²

¹MR Research China, GE Healthcare, Shanghai, People's Republic of China, ²Radiology, Shanghai First People's Hospital, Shanghai, People's Republic of China, ³Neurology, Shanghai First People's Hospital, Shanghai, ⁴MR Research China, GE Healthcare, Beijing, People's Republic of China

This preliminary study used voxel- mirrored homotopic connectivity (VMHC), a novel resting-state fMRI parameter to investigate inter-hemispheric functional activity changes in restless legs syndrome (RLS). Ten RLS patients and ten age- and gender-matched healthy controls were recruited for comparison. The RLS group showed increased VMHC in the amygdala, putamen and insula, as compared to normal controls. Increased VMHC in the insular cortex and putamen might reflect their functions in perception and motor control. Increased VMHC in the amygdalae could be relevant to the disturbed sleep at night, considering its primary role in the processing of memory and emotion.

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