Abstract #1711

Altered Variability in Functional Connectivity of the Anterior Cingulate Cortex in Patients with Refractory and Nonrefractory Major Depressive Disorders

Bochao Cheng^1,2, Gang Ning¹, Yong He³, and Qiyong Gong²

¹Radiology Department, West China Second University Hospital of Sichuan University, Chengdu, People's Republic of China, ²Huaxi MR Research Center, HMRRC, West China Hospital, Sichuan University, Chengdu, People's Republic of China, ³State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, People's Republic of China

Although substantial efforts have been made to elucidate the neuronal basis of both refractory MDD (rMDD) and nonrefractory MDD (nrMDD), the results are inconsistant. We apply the resting-state dynamic functional connectivity (D-RSFC) to explore the divergence of neuroal basis between rMDD and nrMDD. Our results demonstrated that the D-RSFC method can well reveal the dysfunctional brain networks in the MDD. The prefrontal-limbic circuit is the most stable dysfunctional brain network in both MDD subtypes. Additionally, we speculate that the OFC-sgACC circuit, especially the frontal part of the left OFC-sgACC circuit, might be the biomarker for evaluating treatment response in MDD.

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