Abstract #0124

In Vivo Biochemical and Histological Validation of Proton Density Fat Fraction as a Quantitative Biomarker of Hepatic Steatosis

Scott B Reeder^1,2,3,4,5, Curtis N Wiens¹, Nathan Artz^1,6, Jeffrey B Schwimmer⁷, Rashmi Agni⁸, Rao Watson⁸, Tanya Wolfson⁹, Anthony Gamst¹⁰, Guilherme Campos^11,12, Santiago Horgan¹³, Luke Funk¹², Garth Jacobsen¹³, Jacob Greenberg¹², Alexandra Schlein¹⁴, Yesenia Covarrubias¹⁴, Jonathan C Hooker¹⁴, Michael S Middleton¹⁴, Gavin Hamilton¹⁴, Benjamin Ratliff^1,3, Alan B McMillan¹, Diego Hernando^1,2, and Claude B Sirlin¹⁴

¹Radiology, University of Wisconsin, Madison, WI, United States, ²Medical Physics, University of Wisconsin, Madison, WI, ³Biomedical Engineering, University of Wisconsin, Madison, WI, United States, ⁴Medicine, University of Wisconsin, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin, Madison, WI, United States, ⁶Diagnostic Imaging, St. Jude Children’s Research Hospital, ⁷Pediatrics, University of California, San Diego, ⁸Pathology, University of Wisconsin, ⁹San Diego Super Computer Center, University of California, San Diego, ¹⁰Mathematics, University of California, San Diego, ¹¹Surgery, Virginia Commonwealth University, Richmond, VA, United States, ¹²Surgery, University of Wisconsin, Madison, WI, ¹³Surgery, University of California, San Diego, San Diego, CA, United States, ¹⁴Radiology, University of California, San Diego

The purpose of this study was to validate complex- and magnitude-based quantitative chemical-shift encoded MRI (CSE-MRI) to quantify PDFF as an accurate biomarker of hepatic steatosis. A biopsy-MRI correlation study was performed in 95 obese subjects undergoing bariatric weight loss surgery. The results of biochemical triglyceride, conventional histological, digital histological, and MR spectroscopy analyses were used as reference standards. Strong correlations were found between MRI-PDFF measured using both complex- and magnitude-based CSE-MRI methods vs. each reference standard. This is the first cross-sectional in-vivo study validating PDFF as a biomarker of hepatic steatosis using biochemical triglyceride concentration as the reference.

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