As liver fat is heterogeneously distributed, longitudinal changes in liver fat may vary between liver segments. We used confounder-corrected chemical-shift-encoded MRI to examine longitudinal changes in proton density fat fraction (PDFF) of individual liver segments in obese adults following a weight-loss program comprising a very low calorie diet (VLCD) followed by bariatric weight loss surgery (WLS). We observed that changes in PDFF in the 5-month postoperative period vary across segments, with right-lobe segments having more rapid reduction in liver fat.
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