Abstract #0122

Addressing Metabolic Heterogeneity in Clear Cell Renal Cell Carcinoma with Quantitative Magnetic Resonance Imaging

Yue Zhang¹, Durga Udayakumar¹, Ling Cai², Zeping Hu², Payal Kapur³, Eun-Young Kho², Andrea Pavía-Jiménez⁴, Michael Fulkerson¹, Alberto DiazdeLeon¹, Qing Yuan¹, Ivan E Dimitrov⁵, Takeshi Yokoo¹, Jin Ye⁶, Matthew Mitsche⁶, Hyeonwoo Kim⁶, Jeffrey McDonald⁶, Yin Xi¹, Ananth J Madhuranthakam¹, Robert E Lenkinski¹, Jeffrey A Cadeddu⁷, Vitaly Margulis⁷, James Brugarolas⁸, Ralph J Deberardinis², and Ivan Pedrosa¹

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, United States, ³Pathology, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Philips Medical Systems, Cleveland, OH, United States, ⁶Molecular Genetics, UT Southwestern Medical Center, Dallas, TX, United States, ⁷Urology, UT Southwestern Medical Center, Dallas, TX, United States, ⁸Internal Medicine & Kidney Cancer Program, UT Southwestern Medical Center, Dallas, TX, United States

MRI fat fraction (FF, Dixon) and % enhancement (DCE) measurements in vivo in clear cell renal cell carcinoma (ccRCC) were correlated with intracellular fat (Oil Red O), lipidomic profile (mass spectrometry), and cellular metabolomics of tissue samples isolated from anatomically co-registered locations in the same tumor. In vivo FF correlated positively with histologic fat content, spectrometric cholesterol and triglycerides; and negatively with spectrometric free fatty acids and phospholipids. ISUP grade 2 and 3 tumors exhibited marked intra-tumoral heterogeneity in FF whereas grade 4 tumors had reduced lipid accumulation. MRI-derived FF and % enhancement correlated with altered metabolic features of ccRCC.

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