Abstract #4013
Examining intrauterine growth restriction due to placental insufficiency in fetal guinea pigs in utero using MRI
Kevin J Sinclair 1 , Lanette J Friesen-Waldner 1 , Colin M McCurdy 1 , Curtis N Wiens 2 , Trevor P Wade 1,3 , Barbra de Vrijer 4 , Timothy RH Regnault 4,5 , and Charles A McKenzie 1,3
1
Medical Biophysics, University of Western
Ontario, London, Ontario, Canada,
2
Radiology,
University of Wisconsin, Madison, Wisconsin, United
States,
3
Robarts Research Institute,
University of Western Ontario, London, Ontario, Canada,
4
Obstetrics
and Gynaecology, University of Western Ontario, London,
Ontario, Canada,
5
Physiology
and Pharmacology, University of Western Ontario, London,
Ontario, Canada
Growth restricted fetuses have been identified as being
at increased risk of later life metabolic and
cardiovascular disease. The purpose of this study was to
identify developmental abnormalities in growth
restricted guinea pig fetuses compared to healthy
normals using MRI. Two maternal groups were scanned: one
in which branches of the uterine artery were ablated to
promote growth restriction of the fetuses, and a sham
surgical group. Segmentation of anatomical and water-fat
images of pregnant guinea pigs (N = 10) demonstrated
asymmetrical growth restriction as well as a decrease in
adipose tissue in growth restricted fetuses compared to
normal.
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