Abstract #4012
Quantification of Intrapancreatic Fat (IPF) using 1H-MR Spectroscopy and Multi-Echo Dixon: A Feasibility Study
Annelise M Silva 1,2 , Anshuman Panda 3 , Raul Pannala 4 , Vijay P Singh 4 , Krutika Patel 4 , Vishnu T Kommineni 4 , Teresa Wu 5 , Yinlin Fu 5 , and Alvin C Silva 3
1
Research, Mayo Clinic, Phoenix, Arizona,
United States,
2
Arizona
State University, Tempe, Arizona, United States,
3
Radiology,
Mayo Clinic, Phoenix, Arizona, United States,
4
Gastroenterology,
Mayo Clinic, Phoenix, Arizona, United States,
5
School
of Computing, Informatics, and Decision Systems
Engineering, Arizona State University, Tempe, Arizona,
United States
There is increasing evidence that excess intrapancreatic
fat (IPF) has deleterious effects and plays a role in
various disease states including diabetes, pancreatitis,
and the metabolic syndrome. Moreover, it may also
predispose to pancreatic cancer in association with
increased dietary fat intake. At present, IPF assessment
is subjective, without a standardized tool for accurate
noninvasive evaluation. Our goal is to develop and
validate a comprehensive MR imaging protocol for
noninvasive fat quantification of the entire pancreas.
Specifically, MR Spectroscopy and Multi-Echo Dixon
techniques will be optimized and validated for their
efficacy in providing accurate intra-pancreatic fat
(IPF) quantification.
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