Abstract #4014
Assessing renal ischemia/reperfusion injury in mice using time-dependent BOLD and DTI at 9.4T
Dong-Cheol Woo 1 , Do-Wan Lee 1 , Nayoung Kim 1 , Chul-Woong Woo 1 , Sang-Tae Kim 1 , Jeong-Kon Kim 1 , Kyungwon Kim 1 , Youyol Song 1 , Hyun-Kwon Ha 1 , and Jin Seong Lee 1
1
Asan Institute for Life Sciences, Asan
Medical Center, Seoul, Seoul, Korea
The first goal of this study was to quantitatively
assess regional changes in function and
pathophysiological characteristics in renal IR injured
mice and compare data obtained at baseline and following
injury. The second goal was to correlate BOLD and DTI
data using time-dependent scans. Our current findings
suggest that MRI could be used to obtain
pathophysiological data from separate renal compartments
in IR-injured mice. Hence, BOLD and DTI may also provide
functional and pathophysiological data on the allograft
status following kidney transplant without the need to
use a contrast agent.
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