Abstract #3528
Prefrontal and frontal functional connectivity increases in current smokers versus non-smokers
Prantik Kundu 1 and Valerie Voon 2
1
Depts. of Radiology and Psychiatry, Icahn
School of Medicine at Mt. Sinai, New York, NY, United
States,
2
Department
of Psychiatry, University of Cambridge, Cambridgeshire,
United Kingdom
Study of functional connectivity differences between
current smokers and non-smokers demonstrates highly
significant increases in cortico-cortical and
cortical-subocritcal connectivity of prefrontal and
frontal areas associated with nicotine-stimulated
cholinergic pathways. Importantly, connectivity
differences were elucidated based on multi-echo fMRI,
for which seed-based functional connectivity is robust
to motion artifact and associated type I errors in group
comparisons.
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