Abstract #3529
Widespread White Matter Integrity Abnormalities in Cocaine Use Disorder Assessed by High Resolution dMRI and Tractography
Rafael O'Halloran 1 , Nelly Alia-Klein 2 , and Rita Z Goldstein 2
1
Radiology, Icahn School of Medicine at Mt
Sinai, New York, NY, United States,
2
Psychiatry,
Icahn School of Medicine at Mt Sinai, NY, United States
Previously reported white matter changes associated with
cocaine use disorder (CUD) have been limited to focal
areas of fractional anisotropy (FA) reduction in several
areas including the corpus callosum, internal capsule,
and cingulum. In this study, group FA and connectivity
differences were assessed using a state-of-the-art dMRI
protocol. Results indicate a more widespread reduction
of FA in subjects with cocaine use disorder compared to
age-matched controls, corroborating previous findings
but also expanding the territory of white matter
integrity changes implicated in the disease.
Furthermore, connectivity analysis based on tractography
showed that CUD subjects had lower connectivity than
controls in several networks, the most significant of
which was the right side network of the hippocampus,
amygdala, posterior orbito-frontal cortex, and gyrus
rectus.
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