Abstract #3357
Extracting a robust inhomogeneous magnetization transfer (ihMT) rate parameter, ihMT- R ex
Gopal Varma 1 , Olivier M Girard 2 , Valentin Prvost 2 , Guillaume Duhamel 2 , and David C Alsop 1
1
Radiology, Division of MR Research, Beth
Israel Deaconess Medical Center, Harvard Medical School,
Boston, Massachusetts, United States,
2
CRMBM
UMR 7339, CNRS and Aix-Marseille Universit, Marseille,
France
Inhomogeneous magnetization transfer (ihMT) shows
promise for myelin selective imaging. As with other
saturation based techniques, use of the ihMT ratio for
quantification is complicated by other contributions,
such as T
1
and
B
1
inhomogeneity.
Examination of the steady-state signal equation with
saturation suggests use of the inverse signal and
normalization with a high flip-angle (unsaturated)
reference can help eliminate these dependencies.
Application to ihMT data showed the resultant ihMT-
R
ex
parameter
to be B
1
independent
for ihMT saturations of B
1,RMS
≥
50mG. Maps of ihMT-
R
ex
provided
sharper and more uniform contrast within white matter.
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