Abstract #3356
Whole Brain inhomogeneous MT using an ihMT prepared 3D GRE sequence at 1.5T
Olivier M. Girard 1 , Arnaud Le Troter 1 , Gopal Varma 2 , Valentin H. Prevost 1 , Maxime Guye 1,3 , Jean-Philippe Ranjeva 1,3 , David C. Alsop 2 , and Guillaume Duhamel 1
1
CRMBM UMR 7339, CNRS and Aix-Marseille
University, Marseille, France,
2
Radiology
Department, Beth Israel Deaconess Medical Center and
Harvard Medical School, Boston, MA, United States,
3
Ple
d'Imagerie Mdicale, CEMEREM, APHM, Marseille, France
Inhomogeneous Magnetization Transfer (ihMT) has been
proposed as a new technique that provides specific
signal from myelinated tissues. 3D ihMT has been
previously demonstrated at 3T and highlighted
challenges, such as power limitation and non-uniformity
of the resulting contrast. This work presents a 3D ihMT
prepared GRE sequence implemented at 1.5T, allowing for
stronger B
1
and
better RF uniformity. Distributions of ihMTR and MTR
across the whole brain demonstrated notable differences,
and provided great insight for WM characterization. This
opens new horizons for future work on WM microstructure
and to study diffuse WM pathology such as MS.
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