Abstract #3336
Applying variable RF-power CEST (vCEST) to detect exchangeable hydroxyl protons in the presence of MT at 3 Tesla
Daniel James Clark 1,2 , Alex K Smith 3,4 , Michael V Knopp 1 , and Seth A Smith 3,4
1
Wright Center of Innovation, Department of
Radiology, The Ohio State University, Columbus, OH,
United States,
2
Department
of Biomedical Engineering, The Ohio State University,
Columbus, OH, United States,
3
VUIIS,
Department of Radiology and Radiological Sciences,
Vanderbilt University, Nashville, TN, United States,
4
Department
of Biomedical Engineering, Vanderbilt University,
Nashville, TN, United States
In this study we show that a variable RF pre-saturation
power CEST scheme (vCEST) is feasible in vivo. Agar gel
phantoms with glucose are used to show vCEST is
sensitive to hydroxyl moieties in the presence of MT.
Additionally, two subjects with prior ACL injuries are
imaged at 3T and vCEST is used to observe detailed
features of cartilage that are not present with
conventional CEST.
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