Abstract #3337
Improving sensitivity to hydroxyl protons and simultaneous measurement of amide and NOE signals at 3T using variable pre-saturation power CEST (vCEST)
Daniel James Clark 1,2 , Alex K Smith 3,4 , Michael V Knopp 1 , and Seth A Smith 3,4
1
Wright Center of Innovation, Department of
Radiology, The Ohio State University, Columbus, OH,
United States,
2
Department
of Biomedical Engineering, The Ohio State University,
Columbus, OH, United States,
3
VUIIS,
Department of Radiology and Radiological Sciences,
Vanderbilt University, Nashville, TN, United States,
4
Department
of Biomedical Engineering, Vanderbilt University,
Nashville, TN, United States
This study presents theory, simulation, and phantom data
for a variable RF pre-saturation power CEST sequence
(vCEST) that is promising for hydroxyl detection and
simultaneous measurements of amine and NOE signals at
3T. Glycogen and glucose phantoms of varying
concentrations were used to show the increased
sensitivity to hydroxyl protons. Glycogen and BSA
phantoms were used to show that hydroxyl, amide, and NOE
signals can be measured simultaneously in a single
z-spectrum.
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