Abstract #2969
An Exercise-Recovery Protocol Depicts Muscle Perfusion and Capillary Recruitment Heterogeneity in Peripheral Arterial Disease
Jason K Mendes 1 , Christopher J Hanrahan 1 , Jeff L Zhang 1 , Gwenael Layec 2 , Corey Hart 3 , Russell Richardson 3,4 , Sarang Joshi 5 , and Vivian S Lee 4
1
Radiology, University of Utah, Salt Lake
City, Utah, United States,
2
Medicine,
University of Utah, Salt Lake City, Utah, United States,
3
Exercise
and Sports Science, University of Utah, Salt Lake City,
Utah, United States,
4
Medicine,
University of Utah, Utah, United States,
5
Bioengineering,
University of Utah, Salt Lake City, Utah, United States
An exercise-recovery protocol in the MR scanner acts as
a stress test to measure muscle ischemic physiology to
improve diagnosis and management of peripheral arterial
disease (PAD). Evidence suggests changes in the spatial
homogeneity of capillary recruitment may be an earlier
predictor of PAD progression than measures of vascular
reserve. Using an exercise-recovery regimen and arterial
spin labeling we demonstrate varying spatial homogeneity
of capillary recruitment corresponding to disease
progression and exercise induced hyperemia.
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