Abstract #2968
Effects of 24 hour sleep deprivation on cerebral blood flow measured by ASL
Henri Mutsaerts 1 , Torbjrn Elvshagen 2 , Lars Westlye 3 , Atle Bjrnerud 2 , and Inge Groote 3
1
Academic Medical Center, Amsterdam,
Netherlands,
2
Oslo
University Hospital, Norway,
3
University
of Oslo, Norway
The current study investigates the effect of sleep
deprivation on cerebral blood flow (CBF) as measured by
arterial spin labeling. 39 healthy male volunteers, were
scanned on a first morning after sufficient sleep and on
a second morning after either normal sleep (n=20, age
22.7 yrs) or 24 hours supervised sleep deprivation
(n=19, age 21.8 yrs). Whereas the 24 hour test-retest
showed nearly no CBF changes for the normal sleepers,
there were wide-spread perfusion changes for the sleep
deprived. This is the first study to show significant
changes in CBF after sleep deprivation that are not
observed after normal sleep.
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