Abstract #2970
Altered Blood-Brain Barrier Function in Patients with Obstructive Sleep Apnea
Jose A Palomares 1 , Danny JJ Wang 2,3 , Bumhee Park 1 , Sudhakar Tummala 1 , Mary A Woo 4 , Daniel W Kang 5 , Keith S St Lawrence 6 , Ronald M Harper 7 , and Rajesh Kumar 1,3
1
Anesthesiology, University of California at
Los Angeles, Los Angeles, CA, United States,
2
Neurology,
University of California at Los Angeles, Los Angeles,
CA, United States,
3
Radiological
Sciences, University of California at Los Angeles, Los
Angeles, CA, United States,
4
School
of Nursing, University of California at Los Angeles, Los
Angeles, CA, United States,
5
Medicine,
University of California at Los Angeles, Los Angeles,
CA, United States,
6
Lawson
Health Research Institute, London, Canada,
7
Neurobiology,
University of California at Los Angeles, Los Angeles,
CA, United States
Obstructive sleep apnea (OSA) subjects show brain injury
in sites that control autonomic, cognitive, and mood
functions, deficient in OSA. However, the pathological
processes contributing to brain damage in OSA are
unclear, but may include altered blood brain barrier
(BBB) function. We assessed global BBB function and
large artery integrity in OSA and found that BBB
function is compromised, but integrity of large arteries
is intact. The BBB alteration in OSA can contribute to
neural damage that contribute to abnormal functions in
the syndrome. These findings suggest requirement to
repair BBB function in OSA, with strategies
commonly-used in other fields.
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