Abstract #2768
ABTIN: ABsolute TIssue density from NODDI, focusing on myelin density
Farshid Sepehrband 1,2 , Kristi A Clark 3 , Jeremy F. P Ullmann 1 , Nyoman D Kurniawan 1 , Gayeshika Leanage 1 , David C Reutens 1 , and Zhengyi Yang 1,4
1
Centre for Advanced Imaging, University of
Queensland, Brisbane, Queensland, Australia,
2
Queensland
Brain Institute, University of Queensland, Brisbane,
Queensland, Australia,
3
Institute
for Neuroimaging and Informatics, University of Southern
California, Los Angeles, California, United States,
4
School
of Information Technology and Electrical Engineering,
University of Queensland, Brisbane, Queensland,
Australia
This work describes a quantitative approach to obtain
absolute tissue density, focusing on fiber density,
directly from diffusion magnetic resonance imaging. Such
measures can be used to map brain fiber and cell
densities and to quantitatively characterize disease
progression. The proposed technique uses prior knowledge
of myelin and cell membrane densities to correlate
relative intra-cellular and intra-neurite density values
obtained from diffusion magnetic resonance imaging to
absolute tissue density values. The proposed method is
based on the NODDI (neurite orientation distribution and
density imaging) technique, which can be scanned with
clinically feasible acquisition protocol.
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