Abstract #2769
MRI measurement of three-dimensional morphological features of axons
Dan Benjamini 1,2 and Peter J Basser 1
1
National Institute of Health, Bethesda, MD,
United States,
2
Tel
Aviv University, Tel Aviv, Israel
We present an analytical framework to measure the
nonparametric joint radius-length (R-L) distribution of
an ensemble of finite cylindrical pores, and more
generally, the eccentricity distribution of anisotropic
pores. Employing a 3-D d-PFG acquisition scheme, we
first obtain both the marginal radius and length
distributions, and then use these to constrain and
stabilize the estimate of the joint radius-length
distribution, using a feasible number of acquisitions.
Axons are known to exhibit local compartment
eccentricity variations upon injury; the extent of the
variations depends on the severity of the injury.
Reconstructing the eccentricity distribution may provide
information about changes resulting from injury or
development.
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