Abstract #2767
In vivo mouse brain NODDI acquired at 9.4T using cryogenic probe
Van Thu Nguyen 1 , Farshid Sepehrband 1 , Othman Alomair 1 , Suyinn Chong 2 , Karine Mardon 1 , Quang Tieng 1 , Graham Galloway 1 , and Nyoman Kurniawan 1
1
Centre for Advanced Imaging, The University
of Queensland, Brisbane, QLD, Australia,
2
Mater
Research Institute, The University of Queensland,
Brisbane, QLD, Australia
While some studies have used NODDI (Neurite Orientation
Dispersion and Density Imaging) to analyze human
diffusion data, there has not been any study on animal
models. This study fitted NODDI model to two HARDI
(High-angular Resolution Diffusion-weighted Imaging)
shell data (2 b-values and 30 gradient directions)
obtained from the wild type mouse brains. The parameter
maps obtained with NODDI reflect known brain anatomy and
are consistent with fractional anisotropy (FA) maps
obtained with DTI processing, and can be considered a
complement to DTI by offering additional information of
neurite density and their orientation dispersion in both
gray and white matters.
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