Abstract #2267
An Analysis of Variability in Diffusion Tractography of Language Fascicles
Kesshi Marin Jordan 1 , Eduardo Caverzasi 2,3 , Valentina Panara 1,4 , Bagrat Amirbekian 1 , Anisha Keshavan 1 , Nico Papinutto 2,5 , Mitchel Berger 6 , and Roland Henry 2
1
Bioengineering, University of California San
Francisco & Berkeley, San Francisco, CA, United States,
2
Neurology,
University of California San Francisco, San Francisco,
CA, United States,
3
University
of Toronto, Toronto, Canada,
4
Institute
of Advanced Biomedical Technologies, University G.
D'Annunzio", Chieti, Italy,
5
Bioengineering,
University of California San Francisco & Berkeley, CA,
United States,
6
Neurosurgery,
University of California San Francisco, San Francisco,
United States
Diffusion tractography remains the only method of
mapping white matter noninvasively. Fascicle volume
definition depends heavily on tractography
implementation choices. Safe clinical deployment of
these technologies requires methodological variability
to be characterized and minimized. This study
investigates inter- and intra- operator variability of
language fascicle reconstructions in both control
subjects and tumor patients, and their dependence on
#streamlines/voxel threshold choice. These results
indicate that probabilistic tractography methods tend to
have an optimal threshold for maximum percent overlap,
but reliability varies by fascicle. The analysis of
average diffusion metrics show striking average FA
changes between commonly used thresholds.
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