Meeting Banner
Abstract #2268

in a Rat Model of Cerebral Tumor, Exudate Flux is Controlled by Peritumoral Compression

James R. Ewing 1 , Stephen L. Brown 2 , Madhava P. Aryal 1 , Kelly Ann Keenan 3 , Rasha M. Elmghirbi 4 , Swayamprav Panda 1 , Hassan Bagher-Ebadian 1 , and Tavarekere N. Nagaraja 3

1 Neurology, Henry Ford Health System, Detroit, MI, United States, 2 Radiation Oncology, Henry Ford Health System, Detroit, MI, United States, 3 Anesthesiology, Henry Ford Health System, Detroit, MI, United States, 4 Physics, Oakland University, Rochester, MI, United States

In a U251 rat model of cerebral tumor, extracellular volume was measured in the tumor, and in the normal tissue surround of the tumor via an innovative application of the Logan plot. Similarly, tumor exudate flux through the boundary of the tumor was measure via an application of a Patlak plot. Extracellular volume in the normal rim of the tumor was strongly decreased, implying compression in the tumor periphery. In 18 animals, tumor exudate flux was strongly dependent (R2=0.9) on compression of peritumoral tissue.

This abstract and the presentation materials are available to members only; a login is required.

Join Here