Abstract #2266
Cranio-spinal radiation produces long term compromise of white matter tracts in childhood brain tumour survivors.
Logan Richard 1,2 , Eric Bouffet 1,2 , Suzanne Laughlin 1 , Normand Laperriere 3 , Kamila Szulc 1 , Douglas Strother 4 , Juliette Hukin 5 , Christopher Fryer 5 , Dina McConnell 5 , Fang Liu 1 , Jovanka Skocic 1 , Alexandra Mogadam 1 , and Donald Mabbott 1,2
1
The Hospital for Sick Children, Toronto,
Ontario, Canada,
2
University
of Toronto, Toronto, Ontario, Canada,
3
Princess
Margaret Hospital, Toronto, Ontario, Canada,
4
University
of Calgary, Calgary, Alberta, Canada,
5
British
Columbia Children's Hospital, Vancouver, British
Columbia, Canada
Investigating the longitudinal effects of cancer therapy
on childhood brain tumour survivors is important in
understanding their quality of life post-treatment. Our
study investigates the effects of brain tumour treatment
on several white matter (WM) tracts within the brain of
childhood cancer survivors. We used diffusion tensor
imaging to delineate specific WM tracts in brain tumour
patients treated with different therapies and in healthy
children. Survivors treated with craniospinal radiation
exhibit compromised WM within multiple tracts including
the optic radiation and inferior longitudinal
fasciculus. This study provides evidence for the
long-term effects of craniospinal radiation on the
developing brain.
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