Abstract #1930
Comparison of Iron-related MR Susceptibility and Transverse Relaxation Rates in the P19 Cell Model
Linshan Liu 1,2 , Neil Gelman 1,2 , Rebecca McGirr 1 , R. Terry Thompson 1,2 , Frank S Prato 1,2 , Lisa Hoffman 1,2 , and Donna E Goldhawk 1,2
1
Imaging program, Lawson Health Research
Institute, London, Ontario, Canada,
2
Medical
Biophysics, Western University, London, Ontario, Canada
MRI-based cell tracking techniques play an important
role in developing cellular therapy. To improve these
detection methods, we have examined MR measures of iron
contrast in the P19 cell model. We measured the changes
in apparent susceptibility (χa) and transverse
relaxation rates (R2*, R2', R2) in cells cultured in the
presence and absence of iron supplementation. Cellular
iron content was determined using inductively-coupled
plasma mass spectrometry and normalized to the amount of
protein. The change in transverse relaxation rates
showed a stronger correlation to iron levels than did
the change in apparent susceptibility.
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