Abstract #1929
Tracking iron labeled stem cells in bone injury model using MRI
May A Taha 1 , Roman Krawetz 2 , Derrick E Rancourt 2 , John R Matyas 3 , and Jeff F Dunn 1
1
Department of Radiology, Calgary, Alberta,
Canada,
2
Department
of Biochemistry & Molecular Biology, Alberta, Canada,
3
Department
of Comparative Biology and Experimental Medicine,
Faculties of Medicine and Veterinary Medicine,
University of Calgary, Alberta, Canada
Stem cell therapies show significant promise for
stimulating healing of bone injury, but nothing is known
of how stem cells migrate after implant. We developed a
successful iron labeling protocol for embryonic stem
cells. We proved it is possible to track ESCs using
9.4T MRI in a mouse bone injury model and showed that
cells migrated to the marrow and to a second injury
site. We are the first to image ESC migration in bone
injury and, as we did this in mice, it opens the
possibility of using the range of mouse models available
to study bone injury
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