Abstract #1905
Theranostic prospects of gadolinium-based mesoporous silica nanoparticle probes for functional MRI
Veronika Mamaeva 1,2 , Tina Pavlin 3,4 , Didem Sen Karaman 5 , Diti Desai 5 , Melanie Ostermann 1 , Jessica Rosenholm 5 , and Emmet McCormack 1,2
1
Department of Clinical Science, Hematology
Section, University of Bergen, Bergen, Norway,
2
Department
of Internal Medicine, Hematology Section, Haukeland
University Hospital, Bergen, Norway,
3
Department
of Biomedicine, Molecular Imaging Center, University of
Bergen, Bergen, Norway,
4
Department
of Radiology, Haukeland University Hospital, Bergen,
Norway,
5
Laboratory
of Physical Chemistry, bo Akademi University, Turku,
Finland
A novel mesoporous silica nanoparticle MRI probe with
theranostic prospects for targeted drug delivery was
developed and applied to imaging of subcutaneous tumors
in mice. Animals were injected either with Gd-doped
MSNPs, pristine MSNPs, or Dotarem, and T1-weighted RARE
images were collected pre- and at various time points
post contrast injection. We observed a slight, but
significant, increase of SI on T1-weighted images of
GadoNPs-treated tumors at 24 hours. Conclusion: Gddoped
MSNPs are retained for at least 96 hours in tumor tissue
and can be visualized by MRI, suggesting feasibility of
using this NP platform for future theranostic
applications.
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