Abstract #1904
Facilitating the EPR Effect and Improving Tumor Penetration and Nanoparticle Delivery with Ultrafine Iron Oxide Nanoparticle as Observed via Its Dual-Contrast Effect
Jing Huang 1,2 , Liya Wang 1,2 , Hui Wu 1,2 , Lily Yang 3 , and Hui Mao 1,2
1
Laboratory of Functional-Molecular Imaging
and Nanomedicine, Emory University School of Medicine,
Atlanta, GA, United States,
2
Radiology
and Imaging Sciences, Emory University School of
Medicine, Atlanta, Georgia, United States,
3
Surgery,
Emory University, Atlanta, GA, United States
Engineered nanoparticles are delivered to the tumor
mainly through the enhanced permeability and retention
(EPR) effect, which is dependent on and limited by
nanoparticle size. Here we report ultrafine iron oxide
nanoparticles (uIONPs) with a core diameter of 3.5 nm
and dual T1-T2 contrast to facilitate the EPR effect for
improved MRI and drug delivery. uIONPs are highly
dispersed in circulation but can undergo reversible
self-clustering at pH below 7, when entering tumor
interstitial space, leading to switching from bright T1
contrast to dark T2 contrast while promoting tumor
accumulation by 1.6 fold compared to nanoparticles with
larger sizes.
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