Abstract #1762
Sensitivity of CEST MRI for absolute pH measurement in brain metastases
Kevin Ray 1 , James Larkin 1 , Yee Kai Tee 2,3 , Alexandr Khrapitchev 1 , Michael Chappell 3 , and Nicola Sibson 1
1
CRUK and MRC Oxford Institute for Radiation
Oncology, Department of Oncology, University of Oxford,
Oxford, United Kingdom,
2
Department
of Mechatronics and Biomedical Engineering, Faculty of
Engineering and Science, Universiti Tunku Abdul Rahman,
Kuala Lumpur, Malaysia,
3
Department
of Engineering Science, Institute of Biomedical
Engineering, University of Oxford, Oxford, United
Kingdom
CEST-MRI has emerged as a potential
in
vivo
pH
measurement method, but several confounding factors make
absolute pH mapping difficult. Non-invasive mapping of
pH would be useful in the clinic, particularly in the
treatment of brain metastases. We aimed to determine the
sensitivity of CEST to changes in pH, proton
concentration, T
1
and
T
2
in
phantom models of mouse brain and metastatic breast
tumour cells. Three analyses were used to measure CEST
effects, and comparisons drawn. PTR* was found to be the
most sensitive analysis metric, with the potential to
measure pH changes on the order of 0.1pH units.
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