Abstract #1761
Topiramate Induced Intracellular Acidification in Brain Tumors: In-vivo Detection Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging
Kamini Yogesh Marathe 1,2 , Nevin McVicar 1,2 , Alex Li 2 , Mojmir Suchy 3 , Miranda Bellyou 2 , Susan Meakin 2,4 , and Robert Bartha 1,2
1
Medical Biophysics, Western University,
London, Ontario, Canada,
2
Centre
for Functional and Metabolic Mapping, Robarts Research
Institute, London, Ontario, Canada,
3
Chemistry,
Western University, London, Ontario, Canada,
4
Biochemistry,
Western University, London, Ontario, Canada
Lonidamine which is previously used to quantify tumor
selective acidification (decrease in intracellular
pH(pHi)), using a novel chemical exchange saturation
(CEST) method called amine and amide independent
detection (AACID) CEST, is currently not approved to use
in humans. Present study uses the antiepileptic drug,
Topiramate, to quantify tumor selective acidification
using AACID method in mouse model of cancer. After a
single dose of topiramate, significant decrease in tumor
pHi was evident. Further study on tumor selective
acidification by topiramate is needed to determine
whether AACID/CEST effects can be used for tumor
detection and monitoring tumor response to treatment.
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