Abstract #1760
Iopamidol CEST for pH mapping on a 7T scanner: phantom and normal mice kidneys in vivo study
Wei Hu 1 , Phillip Zhe Sun 2 , and Renhua Wu 3
1
the Second Affiliated Hospital of Shantou
University Medical College, Shangtou, GuangDong, China,
2
Athinoula
A. Martinos Center for Biomedical Imaging, Department of
Radiology, Massachusetts General Hospital and Harvard
Medical School, Charlestown, MA, United States,
3
Shantou
University Medical College, Shantou, Guangdong, China
Human tissue lesions are often associated with cell
internal and external disturbance of pH, and most of
them showed the pHe value decreased .1 Therefore the
determination of pHe in the tissue will have certain
value for early diagnosis and identify of diseases. Up
to now, the Iopamidol as a CEST imaging contrast agents
have been reported.1-3 The aim of this study was to
measure pH in vitro and in normal mice kidneys with
Iopamidol use a new method and more simple ratiometric
method on a 7T scanner3.
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