Abstract #1763
Quantitative Measurements of Amide Proton Transfer (APT) Signals and Tissue pH in Acute Ischemic Stroke
Dong-Hoon Lee 1 , Xiaoguang Liu 2 , Kai Zhang 1 , Yi Zhang 1 , Hye-Young Heo 1 , Wenxiao Li 1 , Raymond C. Koehler 2 , and Jinyuan Zhou 1
1
Division of MR Research, Department of
Radiology, Johns Hopkins University School of Medicine,
Baltimore, Maryland, United States,
2
Department
of Anesthesiology, Johns Hopkins University School of
Medicine, Baltimore, Maryland, United States
APT imaging can be used to obtain tissue pH information.
In this abstract, the quantitative measurements of APT
signals and tissue pH in the acute ischemic stroke in
rats were performed using extrapolated semi-solid
magnetization transfer reference (EMR) signals. Our EMR
approach may be helpful for more accurate APT pH
quantification, and useful to understand and identify
the characteristics of the ischemic stroke tissue.
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